Uremia period, the accumulation of waste accumulation in the body can involve many body systems. The decrease of cell function, decrease of enzyme activity, imbalance of water and electricity, and the influence of renal failure on metabolism are mainly manifested in:
Glucose metabolism in patients with uremia: blood glucose slightly increased, the increase is different with the pathogenesis of diabetes, diabetes is the absolute or relative insulin secretion, and hyperglycemia in patients with uremia is mainly reduced cells on insulin sensitivity. Normal people take a certain amount of glucose, and serum insulin increases accordingly. If it is diabetic, this increase is more obvious, which means that more insulin is needed than normal people to make cells use glucose. According to reports, the normal endogenous insulin secretion in patients with uremia, exogenous insulin intake was higher than that of normal people in the body to maintain the level of the insulin can be maintained for a long time in the blood of patients with uremia, diabetic patients with chronic uremia, once appear, can reduce the dosage of insulin.
Protein metabolism disorders: protein metabolism produces nitrogen containing waste, which can accumulate in the body and increase the blood urea nitrogen because it can not drain out of the body. Therefore, in the treatment of patients with uremia, generally limit the intake of protein, malnutrition in patients, patients undergoing long-term hemodialysis, protein intake restriction can be slightly relaxed, the abnormal content of serum amino acids in patients with uremia, some people of some serum amino acid concentration can be higher than the normal 2 to 3 times. On the other hand, the content of essential amino acids in serum may be lower than that of normal people, and the lack of essential amino acids may be greatly affected for the reconstruction of autologous tissues.
Abnormal lipid metabolism: the effect of uremia on lipid metabolism has not been studied very much. Most dialysis patients are known to have elevated levels of glycerol, three, and free fatty acids in the blood. Blood cholesterol and phospholipids are generally normal.