Uremia refers to a variety of kidney disease leading to progressive irreversible renal dysfunction, until the loss of a series of symptoms and metabolic disorders composed of clinical syndrome. Because there is no normal kidney detoxification function, the human body contains nitrogen metabolites and other toxic substances can not be discharged and accumulate in the body, in addition to causing water, electrolyte and acid-base balance disorders, which can cause multiple organ and system lesions. So what causes uremia?
Causes of uremia include direct factors, also indirect factors. Experts pointed out that the direct cause of uremia is half of all types of kidney disease is not timely treatment and the development of late results. Mainly have the following several:
First, glomerular disease: chronic glomerulonephritis, lupus nephritis, etc..
Second, infectious diseases: such as chronic nephritis, renal tuberculosis.
Third, toxic nephropathy: such as drugs, heavy metal poisoning caused by renal failure.
Fourth, metabolic diseases: such as diabetic nephropathy, gouty nephropathy and so on.
Fifth, tubular nephropathy: such as tubular acidosis.
Sixth, renal vascular disease: such as renal arteriolar sclerosis, renal artery stenosis, etc..
Seventh, obstructive nephropathy: such as urinary tract stones, benign prostatic hyperplasia, bladder tumors and so on.
Eighth, congenital, hereditary nephropathy: such as polycystic kidney disease, hereditary glomerulonephritis and so on.
In the above causes, the chronic glomerulonephritis is the most common, accounting for about 50-60%, followed by chronic pyelonephritis, renal arteriosclerosis, urinary stones etc..