Main causes: autosomal recessive, secondary to chronic kidney disease
First, the cause of disease
The etiology of renal diabetes is pided into primary and secondary.
1 primary renal diabetes, also known as familial renal glycosuria (familial renal), mostly autosomal recessive genetic disease, but also some dominant inheritance. The disease can be pided into two types according to the titration curve:
(1) type A: the renal glucose threshold and the maximum reabsorption rate (TMG) of tubular glucose were reduced, and the renal tubular reabsorption of glucose was also lower than that of the normal blood glucose, so it was true. It may be an obstacle to the renal tubular transport alone, but it is often associated with other renal tubular dysfunction, such as Fanconi syndrome, Lowe syndrome, and so on.
(2) type B: decreased renal glucose threshold and TMG is still normal, so it is a pseudo renal diabetes. It is due to the reduction of glucose absorption capacity of inpidual renal units, the maximum absorption rate of glucose is not reached the maximum absorption rate of renal tubular glucose, that is, the threshold of renal sugar is reduced, the clinical common.
2 secondary renal glycosuria is rare, can be secondary to chronic kidney diseases such as chronic interstitial nephritis, nephrotic syndrome, multiple myeloma or other renal toxic substances such as lead, cadmium, mercury, oxalic acid, cyanide and other genetic diseases Fanconi syndrome, Lowe syndrome, cystine storage disease etc..