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Effect of Compound Aminopyrine Phenacetin Tablets on kidney

First, to understand the pain of a piece of adverse reactions and pharmacological toxicology Compound Aminopyrine Phenacetin Tablets (common name), Somidon piece (formerly common name), compound (phenobarbital + phenacetin caffeine + + amid...

Effect of Compound Aminopyrine Phenacetin Tablets on kidney

Aug 13, 2017 by Kidney Disease Expert

First, to understand the pain of a piece of adverse reactions and pharmacological toxicology

Compound Aminopyrine Phenacetin Tablets (common name), Somidon piece (formerly common name), compound (phenobarbital + phenacetin caffeine + + amidopyrin).

aminopyrine phenacetin

Adverse reaction

This compound contains aminopyrine and phenacetin have obvious adverse reactions. Taking the amino group can vomiting, rash, fever, sweating and stomatitis than Lin, neutropenia, few can cause aplastic anemia, exudative erythema, exfoliative dermatitis and glans erosion etc.. The long-term use of phenacetin can cause renal papillary necrosis, interstitial nephritis and acute renal failure, and may even induce carcinoma of the renal pelvis and bladder cancer, can also cause of drug dependence. Phenacetin is also easy to make hemoglobin to methemoglobin, the blood oxygen carrying capacity decreased, resulting in cyanosis, can also cause hemolysis, liver damage, and has a certain effect on the retina.

Matters needing attention

1 long term use of this product can lead to kidney damage, serious can cause renal papillary necrosis or uremia, and may even induce renal pelvic cancer and bladder cancer. Should not be used for a long time, so as to avoid the occurrence of neutropenia, medication more than 1 weeks to regularly check blood.

2 aminopyrine react with food in the stomach, can form carcinogenic N-nitroso compounds, especially nitrosamines, therefore has potential carcinogenicity.

3 long term use can cause dependence and tolerance.

All kinds of pain and invalid traumatic visceral smooth muscle of 4 angina pectoris.

pharmacology and toxicology

As a compound antipyretic analgesic. The aminopyrine and phenacetin can inhibit hypothalamic prostaglandin synthesis and release, the normal reaction recovery thermoregulation and antipyretic effect of receptor neurons; also through inhibition of prostaglandin synthesis and analgesic effect etc.. Aminopyrine and the synthesis and release of prostaglandins inhibit inflammation in the local tissue, stabilize lysosomal enzymes, affect the phagocytic function and play an anti-inflammatory effect. Coffee because of central nervous stimulant, can stimulate the cerebral cortex, improve the induction of the outside world, and contraction of blood vessels, strengthen the first two drugs to alleviate the effect of headache. Phenobarbital has sedative, hypnotic and anticonvulsant effect, can enhance the aminopyrine and phenacetin analgesic effects, and prevention of convulsions caused by fever

 

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