Where does uric acid come from? "Know thyself, know yourself, to overcome the uric acid, we must first understand where it came from. Uric acid is a purine nucleotide in the liver through catabolism, is the purine metabolites in the human body. Purine nucleotides have been a necessary substance in the human body, but if too much purine in the body to produce too much uric acid, or uric acid excretion is insufficient, it will lead to high uric acid levels, the formation of hyperuricemia.
20% of the purine in the human body comes from food, and the body is metabolized in the body by 80%. The body's daily uric acid is about 700 milligrams, of which about 500 mg is excreted through the kidneys through the urine, and the remaining 200 mg is excreted through the gastrointestinal tract. High protein food is a typical high purine food, because the protein can be decomposed in the body to produce purine. Modern people's living conditions are far better than the past, intake of high protein, high fat, high calorie foods increase the proportion, but physical activity is reduced, less consumption and, while the discharge of uric acid did not increase, so it will lead to more and more uric acid, plasma beyond the solubility of load, down in the various organs of the body deposition, cause tissue destruction.
Who is prone to "fourth high"? Generally speaking, male, obesity, family history of gout, high purine diet groups are at high risk of hyperuricemia; diabetes mellitus, hypertension, coronary heart disease, hyperlipidemia and other metabolic diseases associated with hyperuricemia and also occurred very close; long-term use of diuretics, aspirin and other drugs, can lead to increased incidence of hyperuricemia. At the same time, hyperuricemia is an independent risk factor for chronic kidney disease, diabetes mellitus, cardiovascular disease and stroke.
Hyperuricemia is more common in men aged 40~50 years, more than women after menopause. At present, China has reached 120 million of patients with hyperuricemia, and the younger trend is obvious. The blood uric acid concentration of normal male was 150~350 mmol / L, and the female was 100~300 mmol / L. When the concentration of serum uric acid in male was higher than 420 mmol / L, when the female was higher than 360 mmol / L, it could be diagnosed as hyperuricemia.
Hyperuricemia is widespread. When the concentration of uric acid in the blood exceeds its solubility, will precipitate the formation of uric acid crystals, deposited in the corresponding organs, leading to systemic diseases, including gout, high uric acid nephropathy and atherosclerosis, which may eventually lead to joint deformity, uremia. Among them, the greatest risk of gouty arthritis, patients often appear in the middle of the night suddenly severe joints, tearing like pain, serious impact on walking. Gout attacks lasting a few days to a few weeks after remission, usually without sequelae. However, if repeated attacks, a large number of uric acid crystals deposited in the subcutaneous, joint cavity, the formation of gout stone, can cause joint bone destruction, and even lead to joint deformity.
Diet and medication are equally important. Adhere to standardized treatment, can gradually reduce the level of serum uric acid, reduce and prevent the occurrence of complications. Gout attack should first use anti-inflammatory analgesic drugs or hormones, until the symptoms of 1~2 weeks after the start of treatment of uric acid. In the course of treatment, once every 2~4 weeks measured serum uric acid, monitoring the efficacy of treatment; stable period detection of uric acid in the blood every 3 months, 6 months each 3~ review of blood, urine and kidney function, every 6~12 months of liver function, blood glucose, urinary tract ultrasonography.
Hyperuricemia is a lifestyle disease, low purine food intake is particularly important. Foods high in purine include animal offal, seafood, beer, beans, mushrooms, etc.. Beer with seafood is many coastal residents favorite, but the two kinds of food purine content is very high, is hyperuricemia patients diet taboo. Obesity can cause endocrine disorders, so that purine metabolism accelerated, may also lead to increased blood uric acid concentration, so high calorie, high fat diet is not appropriate.