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Causes of chronic kidney disease with continuous development

A healthy person has two kidneys, each with a total of 1 million kidneys. The role of the renal unit is to produce urine, metabolic waste dissolved in the urine excreted. The renal function gradually declines when a loss of the nephron. Cau...

Causes of chronic kidney disease with continuous development

Feb 06, 2017 by Kidney Disease Expert

A healthy person has two kidneys, each with a total of 1 million kidneys. The role of the renal unit is to produce urine, metabolic waste dissolved in the urine excreted. The renal function gradually declines when a loss of the nephron.

Causes of chronic kidney disease progresses can be classified into two kinds, one kind can be summarized as the cause of chronic kidney disease are not removed, continue to act on the kidney; the other is the working unit of the kidney in spontaneous loss.

When there is damage to the kidney, it can cause the loss of the nephron. Give a few examples:

1 hypertension: arterial blood flows into the kidneys, the kidneys can play the role of filtration and excretion of metabolic waste. When blood pressure is too low, there is not enough blood to flow into the kidney, called renal hypoperfusion, cannot give full play to the role of kidney filtration and excretion of metabolic waste, will lead to metabolic waste accumulation in the body; and the blood pressure is too high, the renal perfusion pressure is too high, called renal perfusion, leading to renal injury of renal unit, the unit for a long time the loss will continue. Hypertension can cause kidney disease, kidney disease can also cause hypertension, hypertension and kidney disease are reciprocal causation, forming a vicious spiral. Therefore, it is important to control blood pressure in patients with chronic kidney disease.

2 high blood glucose: kidney disease caused by diabetes, whether the kidney disease is caused by diabetes or other reasons, if cannot control and hyperglycemia, increased kidney filtration burden, long lead to gradual loss of nephron. Therefore, it is important to control blood sugar in the appropriate range.

3 proteinuria: Proteinuria itself is a sign of kidney damage, but also lead to kidney damage substances. Should try to take measures to minimize urinary protein. However, under the current medical technology limitations, chronic kidney disease patients with urinary protein is difficult to subside.

4 drugs: most drugs are excreted by the kidneys, so, as long as medication or infusion, it will increase the burden on the kidneys. It is not desirable that there are people who claim that they are taking protective drugs for kidney protection. Some health care drugs can even directly damage the kidneys, leading to acute renal failure, or a few years after the onset of renal failure. For example, a few years ago, many of the ingredients contain aristolochic acid Longdanxiegan pills, does not appear immediately after taking the decline in renal function, many patients in the withdrawal of the number of years or even 10 years after emerging renal failure. Another cause of chronic kidney disease is a painkiller, because of pain symptoms and long-term use of painkillers can appear chronic kidney disease. Therefore, patients with kidney disease to minimize the use of the type and quantity of drugs, only the use of essential drugs.

5 infection: when any infections, including pneumonia, upper respiratory tract infection, although these infections did not occur in the kidney, but these infections can lead to systemic inflammatory conditions, inflammatory cytokines may act on kidney injury aggravated the already kidney, cause kidney unit lost; may also be because of drug use leads to infection kidney injury; infection or immunological disorder, aggravate autoimmune disease and kidney damage.

6 strenuous exercise: strenuous exercise to produce a large number of metabolic waste, increase the burden on the kidneys. Therefore, patients with chronic kidney disease to avoid strenuous exercise. This is not to say that patients with chronic kidney disease do not need exercise, but to moderate.

 

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