Nephrotic syndrome is a clinical syndrome caused by a glomerular filtration barrier that increases plasma protein permeability and leads to the loss of large amounts of plasma proteins from urine, the main clinical features of a large number of proteinuria, hypoalbuminemia, Hyperlipidemia and edema. The incidence of this syndrome in pediatric kidney disease is only second to acute glomerulonephritis, which is a common glomerular disease in children.
Secondary infection: immune dysfunction, a large number of protein loss, malnutrition and other factors easily secondary to infection. Due to lack of complement system B factor, loss of serum conditioning activity, combined with increased intrahepatic immunoglobulin catabolism and loss from the urine, making the body anti-infective capacity decreased, so easy to secondary infection. Common for respiratory infections, urinary tract infections, skin infections, primary peritonitis, sepsis, intestinal infections, pneumonia and so on.
Hypercoagulable state: most patients are in hypercoagulable state and have the tendency of thrombosis. Many scholars believe that platelet dysfunction is caused by chronic glomerulonephritis nephritis, glomerular damage, capillary coagulation is caused by irreversible glomerular damage. Hypercoagulable state is easy to promote the blood vessel thrombus formation, the glomerulus fibrin calm, the kidney function worsens further. In the course of NS, if the renal vein thrombosis occurs, the congestion in the kidney is more serious, the kidney volume increases, the renal function declines further, edema and proteinuria aggravate.
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