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Am J Kidney Dis: what is the relationship between renal disease and the risk of venous thromboembolism

Studies have confirmed the correlation between the risk of kidney disease and venous thromboembolism, but these results are conflicting, and research information about black is relatively small, recently, a study published in the field of k...

Am J Kidney Dis: what is the relationship between renal disease and the risk of venous thromboembolism

Mar 04, 2017 by Kidney Disease Expert

Studies have confirmed the correlation between the risk of kidney disease and venous thromboembolism, but these results are conflicting, and research information about black is relatively small, recently, a study published in the field of kidney disease J Dis Kidney Journal Am, the researchers aimed to explore the correlation between renal disease and venous thrombosis the risk of embolism.

This study used a prospective cohort study, participants were mainly involved in REGARDS Research (2003 to 2007 to study the reasons for geographic and racial differences in stroke) including 30239 black and white adults over the age of 45. The researchers used creatinine - cystatin C (eGFRcr-cys) equation and urinary albumin / creatinine ratio (ACR) estimated glomerular filtration rate (eGFR). The primary outcome of the study was the diagnosis of venous thromboembolism, and the secondary outcome was the initiation and non initiation of venous thromboembolism. Mortality as a competing risk event.

During 4.6 years of follow-up, the researchers observed a total of 239 venous thromboembolism events at a follow-up of 124624 years. The researchers used a proportional hazards regression model adjusted for age, sex, race, residential area, and body mass index to calculate the specific risk ratio of vte. Compared to eGFRcr-cys 90mL/min/1.73 or m2, the risk of venous thromboembolism eGFRcr-cys60-90mL/min/1.73 m2, 45-60mL/min/1.73 m2, <45mL/min/1.73 M2 adjusted ratio was 1.28 (95% CI 0.94-1.76) and 1.30 (95% CI 0.77-2.18) and 2.13 (95% CI 1.21-3.76). Compared to ACR<10mg/g, the risk of venous thromboembolism, ACR10-30mg/g 30-300 mg/g and more than 300mg/g adjustment ratios were 1.14 (95% CI 0.84-1.56) and 1.15 (95% CI 0.79-1.69) and 0.64 (95% CI 0.25-1.62). The correlation between the induced and non induced venous thromboembolism was similar.

Thus, the lower eGFR (<45 vs. = 90mL/min/1.73 m2) are independent of the correlation with the risk of venous thromboembolism, but there is no correlation between ACR and venous thromboembolism.

 

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