Everyone knows that once we have a lot of proteinuria in our urine, it means that our kidneys have damaged a certain degree of symptoms. What are the dangers of excessive proteinuria? If you want to understand the harm, you will not ignore the occurrence of proteinuria, while avoiding its further development become incurable disease.
Tongshantang experts from harm of proteinuria, proteinuria with mesangial toxicity, namely renal failure model, serum protein accumulation observed in mesangial, aggregation of macromolecules in the mesangial area can cause mesangial cell damage, hyperplasia of mesangial matrix synthesis increased, resulting in glomerular sclerosis. In proteinuria nephropathy, there are low density lipoprotein (LDL) and very low density lipoprotein (VLDL) apolipoprotein B and apolipoprotein A deposition in glomeruli, which eventually lead to glomerulosclerosis. The second is the proteinuria on proximal tubular cell toxicity: the occurrence of proteinuria, the amount of protein in renal tubular epithelial cells into increased to lysosomal activity increased, indicating that protein induced lysosomal spill into tubular cell plasma, subsequent cell injury can stimulate inflammation and scar formation. And then the biological changes of tubular cells caused by proteinuria:
Many renal diseases with proteinuria appear excessive proliferation, which represents a kind of non adaptive reaction, leading to renal failure. More and more evidence that the protein can be directly regulating tubular cell function, change the growth characteristics and phenotypic expression of cytokines and matrix protein, can lead to the release of PDGF and FN tubular basement side and MCP-1 induced fibrosis. Proteinuria aggravates tubulointerstitial hypoxia: Proteinuria reabsorption requires large amounts of protein to digest, which can cause hypoxia in tubular cells, resulting in tubular cell damage.
Through the above tongshantang expert on proteinuria harm explanation, I believe you have a very understanding of it, so the proteinuria is overmuch, cause to the hospital diagnosis and treatment in a timely manner, to avoid the aggravation of kidney damage, develop into a more serious kidney disease.