Pediatric nephrotic syndrome patients and their families should be aware of nephrotic syndrome, there will be edema, swelling and other symptoms, pediatric nephrotic syndrome is characterized by a high degree of edema.
Lower limbs, head and face can have edema, especially the loose parts of the organization is more obvious, such as eyelids, the boy's scrotum can be swollen like a light bulb, as well as visceral serous fluid, such as pleural effusion and ascites. The skin of patients with serious edema is thin and translucent, there is water percolation when skin is slightly injured. Edema affect the blood circulation, so that local resistance decreased, prone to infection.
Plasma colloid osmotic pressure decreased
The exchange of blood vessels inside and outside the body by its osmotic pressure on both sides of the regulation. Osmotic pressure, including osmotic pressure and colloid osmotic pressure, the former is from the crystal material (mainly electrolyte), because it can freely go through the capillary wall, it has little effect on the internal and external fluid exchange. The latter mainly comes from the protein (which is mainly albumin), because it can not freely go through the capillary wall, it is a major factor in the exchange of fluids within and outside the blood vessel. Nephrotic syndrome, due to a large number of plasma protein loss from the urine, causing hypoproteinemia, resulting in decreased plasma colloid osmotic pressure, when the normal 3.3 ~ 4kpa down to 0.8 ~ 1.1kpa, the intravascular moisture into the hypertonic Interstitial fluid movement, and edema occurred.
Effective blood volume reduction
Plasma water shift to reduce the effective blood volume, which led to the following changes in the body: through the capacity of the sensor to increase antidiuretic hormone (adh), renal tubular reabsorption of water increased. Through the excitatory renin - angiotensin - aldosterone system, resulting in secondary aldosteronism, renal tubular reabsorption increased. Inhibit the production of natriuretic factors, so that reduce the renal excretion of sodium. So there is water, sodium retention of body, further aggravated edema.
Aimed at causes we should have appropriate treatment, for children with nephrotic syndrome, we must have early detection, early treatment, so as not to affect the recovery of the disease. Hope that the above content can help everyone.