Nephrotic syndrome is a common pediatric kidney disease, is due to a variety of causes caused by tight ball basement membrane permeability increased, a large number of protein from the urine lost clinical syndrome. The main features are a large number of proteinuria, hypoalbuminemia, severe edema and hypercholesterolemia. According to its clinical manifestations are pided into simple nephropathy, nephritis kidney disease and congenital nephropathy three types. In children under 5 years of age, nephrotic syndrome, pathological types are mostly minor lesions, and older pathology type to non-minor lesions (including mesangial proliferative glomerulonephritis, focal segmental sclerosis, etc.) mostly.
Age and age of onset, preschool for the incidence of peak. Simple onset age is too small, tight length is long. Men are more than women, male: female about 1.5 ~ 3.7: 1. Edema is the most common clinical manifestation. Often found for the earliest parents. From the eyelid, face, gradually and limbs body. Edema can be concave, there may be serous effusion such as pleural effusion, ascites, boys often significant scrotum edema. Weight can be increased by 30% to 50%. Severe edema in children with thighs and upper arm medial and abdominal skin can be seen skin white or purple pattern. The severity of edema is usually independent of prognosis. Edema at the same time often reduce urine output. In addition to edema, the children may be due to long-term loss of protein protein malnutrition, manifested as pale, dry skin, hair dry withered yellow, finger nails appear white stripes, ear and nasal cartilage weak. Children with mental malaise, fatigue, loss of appetite, sometimes diarrhea, may be associated with intestinal edema and or associated with infection. The disease is long or recurrent. Nephritis children may have increased blood pressure and hematuria symptoms.
Response measures: the use of adrenal cortical hormone-based comprehensive treatment of Chinese and Western medicine. Treatment includes control of edema, maintenance of water and electrolyte balance, supply of adequate nutrition, prevention and control associated with infection, proper use of adrenal cortex hormones. Recurrent or hormonal resistance with the application of immunosuppressive drugs. Chinese medicine is currently to spleen and kidney, with the control of Western medicine side effects as the main rule. Cause: The pathogenesis has not been elucidated. Minimal lesions may be associated with T cell immune dysfunction. Membranous nephropathy and membranous proliferative glomerulonephritis may be associated with the formation of immune complexes. Prone age: prone to all ages.