Infection is the most common complication and the main cause of death; according to the research of pediatric nephrology 1984 International Organization (ISKDC) statistics, directly or indirectly, died of infection accounted for the death of 70%. infection in children with nephrotic syndrome is often recurrent and / or exacerbation and guide, and can affect the hormone effect.
The causes of infection are: humoral immunity (immune globulin in the urine loss, decreased synthesis of increased catabolism); II is often accompanied by cellular immunity and complement system is insufficient; the protein malnutrition, local circulation disorder caused by edema; the common application of corticosteroids, immunosuppressive agents.
Bacterial infection in previous infection of pneumococcal infections caused by bacteria, in recent years also increased (such as Escherichia coli). Common respiratory infections, urinary tract infections, skin erysipelas and primary peritonitis. Generally do not advocate preventive use of antibiotics for investment, the effect is not reliable, and easy to cause the proliferation of bacteria and drug resistant strains dysbacteriosis; but when infection occurs, should be treated actively.
Children are more sensitive to virus infection, especially in the process of glucocorticoid and immunosuppressants accepted, with chicken pox, measles, herpes zoster disease often than the general children; to contact history, hormone and immunosuppressant can temporarily reduce, and give the gamma globulin injection. After temporarily cause measles infection the inpidual reported nephropathy remission.