What are the matters needing attention for the diagnosis of nephrotic syndrome? Nephrotic syndrome is the most common kidney disease, then how to diagnose whether suffering from nephrotic syndrome? What are the diagnosis of nephrotic syndrome? Let's take a look at it.
The diagnostic criteria for nephrotic syndrome are: (1) urinary protein more than 3.5g / d; (2) plasma albumin less than 30g / L; (3) edema; (4) elevated blood lipids. Of which urinary protein and plasma albumin are the most important of diagnosis of nephrotic syndrome.
First to introduce proteinuria, in normal physiological conditions, glomerular filtration membrane have molecular barrier and charge barrier effect, when the effect of barrier, especially when the charge barrier is impaired, the permeability of glomerular filtration membrane to plasma proteins increased, resulting in increased protein content in the original urine, far more than the proximal tubule back to the amount of absorption, the formation of a large amount of proteinuria. On this basis, all factors that increase glomerular pressure and lead to high perfusion and high filtration are likely to exacerbate urinary protein excretion.
Then the changes in plasma protein, nephrotic syndrome, a large amount of albumin lost from the urine, to promote the compensatory synthesis of albumin in the liver and the increase in renal tubular decomposition. When the increase liver albumin synthesis is not strong enough to overcome the loss and decomposition, appeared hypoalbuminemia. In addition, patients with nephrotic syndrome due to gastrointestinal mucosal edema caused by eating decline, lack of protein intake, poor absorption or loss, but also the cause of hypoalbuminemia.
Then is edema, nephrotic syndrome, low albuminemia, plasma colloid osmotic pressure drop, so that water enter into the tissue gap from the blood vessels, it is the basic cause of nephrotic syndrome edema. Recent studies have shown that about 50% of patients with normal or increased blood volume, plasma renin levels normal or decreased, suggesting that some of the original in the kidney of sodium, water retention factors play a role in nephrotic syndrome.
Finally, hyperlipidemia, high cholesterol and hypertriglyceridemia, serum LDL, VLDL and lipoprotein concentration increased, often associated with hypoalbuminemia. Its mechanism and liver synthesis of lipoprotein increased and decreased decomposition of lipoprotein, at present, the second one is considered that is more important reason of hyperlipidemia.
The above is our introduction on the diagnosis of nephrotic syndrome, for reference only. If there are questions about nephrotic syndrome, you can leave a message below, we will reply to you as soon as possible.
What are the matters needing attention for the diagnosis of nephrotic syndrome?