1、Infection:due to a lot of immune globulin is lost from urine, the decreased of plasma protein, influence the formation of antibody. The application of adrenal cortex hormone and cytotoxic drugs decrease systemic resistance, easy to have infection, such as skin infection、primary peritonitis、respiratory tract infection、urinary tract infection, even though cause to septicemia.
2、Coronary heart disease: nephrotic syndrome patients always have hyperlipidemia and hypercoagulable state, so be easy to cause coronary heart disease. Some reports showed that the incidence rate of myocardial infarction for nephrotic syndrome patients is higher eight times than normal people. Coronary heart disease has been become the third factor that the reason causes to die for nephrotic syndrome patients.
3、The formation of thrombus: the patients with nephrotic syndrome are easy to have thrombus, especially for the incidence rate of membranous nephropathy is up to 25-40 percent. The reasons for formation of thrombus have edema、less activities、venous stasis、hypertension、high content of fibrinogen and increased v、VII、VIII、x growth factor and etc.
4、Acute renal failure: nephrotic syndrome patients are in hypovolemia and hypercoagulable stste due to a lot of proteinuria、hypoproteinemia、hyperlipidemia. Vomiting、diarrhea、using antihypertention drugs and diuretic, all of these will decrease the blood perfusion of kidney, and decline the glomerular filtration rate, give rise to acute renal failure. In addition, nephrotic syndrome with renal interstitial edema, protein concentration formed tube block the renal tubules also could cause to renal failure.
5、Electrolyte and metabolism disorder: repeated use diuretic or unreasonably limit salt for a long time will cause to hyponatremia for nephrotic syndrome patients; using adrenal cortex hormone and a lot of diuretic cause to discharge a lot of urine, if don’t supplement potassium, will cause to hypokalemia.