Because of membranous nephropathy in early may have no symptoms or symptoms are not obvious, so many patients are unable to detect the disease by subjective feeling, general membranous nephropathy is through a series of formal examination to be diagnosed, so what are the inspection methods for early membranous nephritis?
Membranous nephropathy with primary and secondary, and other related methods are basically the same, primary membranous nephropathy laboratory tests are mainly proteinuria, hypoalbuminemia, hyperlipidemia and lipids. Usually serum levels of C3, C4 and other complement components are normal and free of circulating immune complexes. In the activity of MN, urine C5b-9 was significantly increased. To exclude secondary causes, the need for hepatitis B virus, hepatitis C virus, syphilis, lupus nephritis and other connective tissue disease and tumor markers and other immunological detection.
Through the examination of the patient's urine, you can find the relevant data anomalies. Almost all cases have proteinuria, more than eighty percent of the cases of urinary protein ≥ 3.5g / 24h, severe cases can be ≥ 20g / 24h. Usually non-selective proteinuria, but 20% of the cases may be selective proteinuria. Urine C5b-9, C3 increased, suggesting that MN in the active period. Severe proteinuria, urinary C5b-9 can also increase. Usually have microscopic hematuria, but the naked eye hematuria rare. Severe renal disease in patients with obvious hypoproteinemia, other, such as IgG can also be reduced; elevated blood lipids, showed low density and very low density lipoprotein were elevated, but with the reduction of urinary protein, hyperlipidemia can be restored to normal.
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