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What are the main factors of lupus nephritis ?

The morbidity of lupus nephritis is not casual , it is the kidney disease caused by systemic lupus erythematosus without effective treatment ,so besides this factor ,what are the main factors of lupus nephritis ? 1.Mental factor .the resear...

What are the main factors of lupus nephritis ?

Dec 03, 2013 by Kidney Disease Expert

The morbidity of lupus nephritis is not casual , it is the kidney disease caused by systemic lupus erythematosus without effective treatment ,so besides this factor ,what are the main factors of lupus nephritis ?

1.Mental factor .the research shows that psychological stress can not only promote lupus nephritis disease activity ,but also may be the onset factors of lupus nephritis .However ,the intensity of stress responses to individual strength affected by individual quality 、personality characteristics and the strength 、duration and frequency of the stressful events .

2.Sex hormone .Pregnancy can make half of the patients deterioration .Experimental animals with lupus nephritis to estrogen will make the illness aggravate ,if give androgen will make the illness relieve .It found that both men and women with lupus nephritis ,its estrone hydroxylation products are increased ,while testosterone is reduced .

3.Genetic factors .The recent research shows that genetic factors play decisive role in the onset of lupus nephritis .Patients with lupus nephritis can have family history ,which a close relative prevalence is higher .The relevance ratio of HLA-DR2 is obvious higher than normal people ,HLA-DQW1、HLA-DQW2、HLA-B8 are commonly seen .In addition ,lack of C2、C4、Clr and Cls will easily occur lupus nephritis .

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