Early diagnosis of drug related ARF is the key to determine the prognosis of patients. Therefore, detailed attention to the medication history of unexplained acute renal failure patients, allergy history is extremely important to suspicious cases immediately stopped to observe suspicious drugs, when necessary, timely renal biopsy often is helpful to the diagnosis.

The analysis showed that most of the patients who needed to rely on renal biopsy diagnosis were atypical clinical manifestations. The original glomerular disease was based on the presence or presence of renal tubular and tubulointerstitial lesions;

For those with typical acute renal tubular necrosis or acute interstitial nephritis, as long as physicians are vigilant, clinical diagnosis can be made

But in these patients, after treatment with systemic allergic manifestations rarely, drug fever incidence rate is only 4.8%, the incidence of skin rash is only 16.7%. because of its clinical manifestations are not specific, and the lack of specific and sensitive means of detection, clinical easy, missed diagnosis.

Hyponatremia and hypernatremia: due to vomiting, diarrhea, excessive sodium loss, renal tubular sodium reabsorption less susceptible to hyponatremia. If a sudden increase in sodium intake, prone to water and sodium retention, hypertension, edema and heart failure.

High potassium and hypokalemia: renal failure less urinary potassium excretion decreased. Increase of catabolism, metabolic acidosis, transfer to the extracellular K +, the use of retention of potassium diuretics or angiotensin-converting enzyme inhibitors, can lead to severe hyperkalemia.


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