The joint pain and kidney damage of high uric acid, make people suffer from pain. People often find it difficult to pay attention to their own life habits and eating habits. As a result, uric acid drugs have become a regular medicine for many people. What are the drugs that can reduce uric acid? What's the difference?
A drug that promotes uric acid excretion
Benzbromo Malone: uric acid excretion disorders, benzbromo Malone is the main treatment drug, suitable for primary and secondary hyperuricemia, gouty arthritis intermission and gouty tuberosity. The adult initial dose of benzbromine Malone was 25-50 mg a day, and 2-5 weeks later, the dosage was adjusted to 75-100 mg according to the blood uric acid level, and after one breakfast every day.
Caution: benzoic bromine Malone is forbidden in patients with uric acid renal calculi. The rate of glomerular filtration rate is less than 20ml/min, and the daily dosage of mild to moderate renal failure should not exceed 50 mg. Mild adverse reactions, nausea, diarrhea, occasionally appear stomach discomfort, may have impaired liver function, urticaria and itching and other skin allergies.
The use of probenecid: at present, probenecid has gradually fade out: the reason is adverse effect on liver and kidney of the heavier, larger, possibly acute gout attacks. The condition is too harsh. The use of this medicine needs more than 50-60ml/min of glomerular filtration rate, and the requirement for urine pH is not acidic. There is no urolithiasis or related history, and salicylic acid can not be used.
Inhibition of uric acid generation drugs
Non - Bu: a lot of patients reflect this medicine is effective, it is a little expensive. It can be used for long-term treatment of hyperuricemia. It is still safer to use liver metabolism, renal insufficiency, and kidney transplant patients. The initial dose of the non - inbud was 20-40 mg/ days, and the maximum dose was 80 mg/ days. Precautions: careful use of severe renal insufficiency.
Allopurinol: clinical use for more than 40 years, the treatment can be used for a wide range of primary and secondary hyperuricemia, recurrent gout and chronic gout, gout, uric acid stones of kidney stones and uric acid nephropathy. Allopurinol: one tablet a day for 100 mg, glomerular filtration rate than 30mi/min reduction.
Precautions: glomerular filtration rate is forbidden when 15ml/min. It is easy to cause skin allergy, and fatal exfoliative dermatitis can occur in severe cases. Recommend taking allopurinol before the screening of HLA-B*5801 gene, positive disable.
Uric acid can not be ignored, and the control of uric acid can reduce the risk of gout and renal failure. People who have more than 10 years of gout history should check their renal function and find early treatment. The above drugs should be used under the guidance of the doctor.