Hyperuricemia is a metabolic disorder caused by an increase in uric acid synthesis and / or a decrease in uric acid excretion caused by a purine nucleotide metabolic disorder. The clinical study found that hyperuricemia occurred in addition to disease and obesity, diabetes, dyslipidemia, hypertension, atherosclerosis and coronary heart disease are closely related, but also with the long-term use of some drugs - drugs affect the excretion of uric acid, uric acid excretion disorder, resulting in increased blood uric acid level in hyperuricemia may even cause gout.
Diuretic induced by blood volume reduction effect can increase the weight of uric acid in the proximal tubule absorption, long-term use can appear with hyperuricemia, medullary loop and thiazide diuretics are more obvious, such as furosemide and torasemide, hydrochlorothiazide etc.. Diuretics should not be used for patients with hypertension and hyperuricemia and gout, for taking diuretics and patients with gout and avoiding the use of thiazide diuretics and alkaline urine, drink more water, keep the daily urine volume in more than 2000ml.
Clinical studies have found that norfloxacin, ciprofloxacin, ofloxacin and other quinolones have the risk of hyperuricemia, but the mechanism is not yet clear, and these drugs may be related to the kidney mechanical damage and renal tubular secretion dysfunction caused by this kind of medicine.
The effect of aspirin on uric acid metabolism is bi-directional: small doses of aspirin can cause uric acid retention, and when high doses of aspirin use uric acid excretion. Therefore, long-term use of low-dose aspirin may cause hyperuricemia.
The effect of allopurinol on uric acid metabolism is also bi-directional: low-dose use of allopurinol, uric acid can compete for excretion, uric acid excretion to reduce, and high doses of allopurinol can reduce uric acid production. Therefore, long-term low-dose use of allopurinol can cause hyperuricemia.
Five Vitamin C
High dosage (daily dosage is greater than 3G) can increase the oxalate content in urine more than 10 times, which can lead to hyperuricemia
Six beta blockers
Can reduce the renal blood flow and glomerular filtration rate, reduce uric acid excretion, especially in combination with diuretics, easy to cause hyperuricemia.
Fructose into the body lead to ATP depletion and the formation of a large number of AMP, ATP depletion will increase the activity of purine metabolic enzymes to accelerate the production of uric acid, leading to increased intracellular uric acid and hyperuricemia. Studies have shown that regardless of a single intake or a large number of long-term consumption of fructose can lead to increased serum uric acid, thereby increasing the risk of gout.
Eight anti-tuberculosis drugs
Pyrazinamide and ethambutol and other anti-tuberculosis drugs can cause hyperuricemia. This is because these drugs and their metabolites compete with uric acid excretion pathways to reduce uric acid excretion, causing hyperuricemia.
Nine tumor chemotherapeutic agents and glucocorticoids
Cytotoxic chemotherapy drugs and glucocorticoids for the treatment of hematological malignancies (such as leukemia, lymphoma, etc.), the number of cell death can be a sharp increase in purine degradation increased, causing uric acid accumulation induced hyperuricemia.
Large doses of niacin, there may be a phenomenon of elevated uric acid, niacin derivatives acycamycin will not cause elevated uric acid.
Eleven immunosuppressive agents
Cyclosporine and other immunosuppressive agents can lead to renal hemodynamic disorders, direct renal toxicity, affecting the excretion of renal function, thereby affecting the secretion and excretion of blood uric acid.
Twelve trypsin preparations
Trypsins are extracted from the animal's pancreas and contain large amounts of purines. Prolonged use of large doses can lead to hyperuricemia.
Inosine is the intermediate product of purine metabolism. The final product in the body metabolism is uric acid, long-term use can cause hyperuricemia.
The drug into the body can be metabolized into high vanillic acid and bitter almond acid, these two substances will compete with uric acid excretion pathways, so that uric acid excretion decreased, causing hyperuricemia.
Fifteen foods containing ethanol
Ethanol can induce glycogen dysplasia, resulting in lactate and ketone body accumulation, lactic acid and ketone body β-hydroxybutyric acid competitive inhibition of uric acid excretion, and cause hyperuricemia.
Because the drug induced hyperuricemia is usually reversible, the withdrawal will soon return to normal, if not stopped, during the use of these drugs should be more water, keep the daily urine volume is more than 2000 ml, in order to promote the excretion of uric acid. Sodium bicarbonate can be taken orally to digest urine if necessary.
After the treatment of uric acid value is still high, should immediately stop using the drug can cause hyperuricemia and timely medical treatment.