Proteinuria is a common symptom of kidney disease symptoms, when we go to the toilet find proteinuria, to go to the hospital for examination, diagnosed with kidney disease. Then, what are the dangers of albuminuria, and what harmful will it do to our bodies?
1, causing tubulointerstitial hypoxia: Proteinuria reabsorption digestion of large amounts of protein requires additional energy, can cause tubular cells hypoxia, resulting in tubular cell damage.
2, the proximal tubule cell toxicity: the occurrence of proteinuria, the amount of protein in renal tubular epithelial cells into increased to lysosomal activity increased, indicating that protein induced lysosomal spill into tubular cell plasma, subsequent cell injury can stimulate inflammation and scar formation.
3. The biological changes of tubular cells: many renal diseases with proteinuria have cell proliferation, which represents a kind of non adaptive reaction, which leads to renal failure. More and more evidences show that proteins can directly regulate the function of tubular cells, change their growth characteristics and the expression of cytokines and matrix proteins, and induce the process of fibrosis.
4, mesangial toxicity: in renal failure model, can be observed in the accumulation of serum protein in mesangium, aggregation of these macromolecules in the mesangial area can cause mesangial cell damage, hyperplasia of mesangial matrix increased synthesis, resulting in glomerulosclerosis. In the proteinuria nephropathy model, there are low density lipoprotein and very low density lipoprotein apolipoprotein B and apolipoprotein A deposition in the glomerulus, and these aggregates can eventually lead to glomerulosclerosis.
Since the harm of proteinuria is so serious that we have to do the prevention of kidney disease in daily life, when proteinuria appear, should to timely treatment, the urine protein has great harm, can cause serious damage to the body, so we have to do to prevent kidney disease, avoid the occurrence of proteinuria.
What does the harm that albuminuria have to the human body?