Home > hypothyroidism and kidney problems

hypothyroidism and kidney problems

Written by admin | Published on 2017-06-22


Primary hypothyroidism (hypothyroidism) due to systemic low metabolism caused by thyroid gland disease itself hypothyroxinemic or thyroid hormone resistance syndrome caused by thyroid hormone. The main function is to promote the material and energy metabolism, promote the growth and development process. When Hypothyroidism Thyroid hormone deficiency when the body. The thermal effect of sugar, fat and protein, slow metabolism caused by anemia, cardiovascular disease, hyperlipidemia, myocardial enzyme change, mucous edema. The clinical manifestation is chills, fatigue, dry, rough skin, high cholesterol, myxedema, hoarseness, bradycardia and other symptoms.

For FT3, FT4, TSH and its relationship with renal function, rarely reported in domestic literature. Recent reports of renal function in patients with primary hypothyroidism decreased. Many studies showed that patients with primary hypothyroidism BUN, Scr, UA, the positive rate of urinary protein was significantly higher than the normal control group, CCr, GFR (glomerular filtration rate) is lower than the normal control group, but the decline in renal function has nothing to do with TSH and FT4, FT3 decline is the main cause of renal dysfunction, including FT3 and CCr, GFR changes were positively correlated, and UA changes were negatively correlated.

Thyroid hormone is one of the main factors of GFR. FT3 is the activated form of thyroid hormones play a physiological role in the cell, but also affect the renal function of primary thyroid hormone, hypothyroidism associated renal damage is TSH first increased, followed by FT4, TT4, FT3 and TT3 decreased, there is a visible change the sequence and different features.

Hypothyroidism mechanisms leading to renal damage: because thyroid hormone deficiency leads to low metabolism in the body, organ dysfunction, reduced protein synthesis, muscle weakness, mucin tissue increased, with a positive ion and a large number of water molecules, caused by mucous edema, interstitial water and sodium retention, increased capillary permeability, blood capacity is reduced. The patients with hypothyroidism due to mucopolysaccharide deposition and (or) autoimmune factors in renal glomerulus, renal tubular basement membrane thickening, proliferation of endothelial cells, renal tubular epithelial cell cytoplasm and increase the content of the reduced blood flow, renal vasoconstriction, GFR and RPF (effective renal plasma flow) decreased. The glomerular functional lesion renal tubular damage is more obvious. The hypothyroidism. Reduced blood volume, plasma ANP release decreased, GFR decreased. The hypothyroidism due to myocardial myxedema caused by myocardial contractility of heart injury. Bradycardia, cardiac output decreased. The hypothyroidism associated with elevated blood lipids, vascular atherosclerosis prone to resulting in systemic vascular resistance increased.

The pathological types of hypothyroid renal damage including membranous nephropathy, mesangial proliferative nephropathy, focal segmental glomerulosclerosis, minimalchange nephropathy, the most common membranous nephropathy. Some scholars reported deposition of visible thyroid microsomal antibody in the glomerulus, show that immune mechanism may play a role in autoimmune thyroiditis associated nephropathy, need a large sample of cases confirmed.

Clinical hypothyroidism often because the performance of non specificity was misdiagnosed, and renal dysfunction is rarely reported. Patients with hypothyroidism, glomerular capillary pressure and glomerular filtration membrane leads to plasma protein leakage injury and proteinuria. Both hypothyroidism and chronic renal failure patients with EPO (erythropoietin) normocytic normochromic anemia associated with hypothyroidism. Body basal metabolic rate is low, the use of reduced oxygen, oxygen saturation increased, to reduce the production of EPO kidney; anemia of chronic renal failure is the kidney itself produces EPO reduced. Therefore, hypothyroidism patients often appear blood Cr, UA increased, CCr decreased, abnormal renal function, urinary protein, edema, anemia. Clinically misdiagnosed as nephritis. Therefore, patients with clinical edema, renal dysfunction, urinary protein positive without nephropathy and normal renal ultrasound for the thyroid should pay attention to Gland function checks to avoid some unnecessary examinations, especially traumatic examination such as renal biopsy. According to the dynamic changes of renal function and serum TSH, FT3, FT4 levels can be found in patients with primary hypothyroidism, to avoid misdiagnosis and has important clinical significance for the prevention of medical risk. Other patients with hypothyroidism the disease should pay attention to the monitoring of renal function to the medication guide.

Hypothyroidism Thyroid hormone deficiency, can promote kidney damage from many aspects, and increased with increasing degree of hypothyroidism, resulting in renal fibrosis, renal failure. Severe primary hypothyroidism appeared late, swelling and kidney damage, clinical manifestations resembling primary chronic glomerular nephritis end-stage. Hypothyroidism can cause kidney function decline, but the functional impairment of renal function, can be reversed by thyroid hormone therapy, correction of hypothyroidism, renal function can be restored.


Disclaimer: this article only represents the author's personal opinion, not the website. Its originality and the statement text and content without the site confirmed that for all or part of this paper and the content, the authenticity of the text, the integrity, timeliness in this website do not make any commitment or promise, please readers for reference only, and please check the related content. If you have any questions, please consult the online expert!

Related articles
  • Invisible damage to the kidneys, these ch
    Invisible damage to the kidneys, these chemicals in life hav

    Modern medical research has found that some of the chemical elements contained in general household products are related to acute and chronic kidney diseases. However, if you carefully read the product descriptions and take some precautions...


  • Peritoneal dialysis, do you really unders
    Peritoneal dialysis, do you really understand?

    Peritoneal dialysis is a dialysis treatment for uremic patients. An abdominal surgery is performed before dialysis, and a soft and flexible abdominal tube is placed in the abdominal cavity. During dialysis, a special liquid called abdominal...


  • Do kidney disease patients have a kidney
    Do kidney disease patients have a kidney biopsy?

    Renal biopsy is the abbreviation of renal biopsy. It is an important means to obtain renal pathological specimens. It is an important basis for the diagnosis of kidney disease, selection of treatment plans, and prognosis. The correction rat...


  • Under what circumstances can patients wit
    Under what circumstances can patients with kidney disease be

    From 12 weeks of gestation to delivery, renal blood flow and glomerular filtration rate can be increased by 30%-50%. The long diameter of the kidney can be increased by 1 cm and returned to normal within 6 months after delivery. Due to chan...


  • What should I do if kidney failure causes
    What should I do if kidney failure causes kidney damage?

    Renal insufficiency is a disease that threatens a lot of health for patients. If treatment is not timely and causes kidney failure or uremia, it is undoubtedly the death penalty for life. What are the matters? First, how to treat kidney dam...


  • Who is prone to kidney stones?
    Who is prone to kidney stones?

    Kidney stones, as the name suggests, are stones in the kidneys. In the various organs of the urinary system, the kidneys are usually the site of stone formation. Kidney stones are one of the common diseases of the urinary system. One in eve...


  • In which case do you need a kidney biopsy
    In which case do you need a kidney biopsy?

    First of all, let me introduce what kind of premise is required for kidney biopsy. Renal biopsy for histopathological examination is the most commonly used diagnostic tool for kidney disease. It is not only used for the pathological diagnos...


  • Mixed drugs can cause liver and kidney da
    Mixed drugs can cause liver and kidney damage, poisoning, al

    Many cold medicines, antipyretics and painkillers contain paracetamol. If you use two cold medicines at the same time, or eat antipyretics and analgesics at the same time, causing excessive consumption of paracetamol, it will cause acute li...


  • Can kidney stones be discharged from the
    Can kidney stones be discharged from the patient's urine?

    Kidney stones are a very serious urinary disease. Generally, when people have stones in the kidneys, their health will be greatly affected. Kidney stones will also have great harm to patients lives and work, so patients are needed. I went t...


  • Why does the tonsils cause kidney damage
    Why does the tonsils cause kidney damage after inflammation?

    The tonsils are one of the bodys immune organs and one of the important safety guards of the human body. It is said to be immune organs because the tonsils are densely packed with abundant lymphoid tissues. They can produce a large number o...


  • Why do patients with kidney disease do no
    Why do patients with kidney disease do not recommend eating

    MSG is a kind of sodium salt containing umami. The scientific name is sodium glutamate, also known as glutinin. In addition, it contains a small amount of salt, water, fat, sugar, iron, phosphorus and other substances. Chicken essence is a...


  • How do kidney patients choose a vaccine?
    How do kidney patients choose a vaccine?

    The so-called vaccine refers to a biological product for vaccination made of various pathogenic microorganisms. Vaccines made of bacteria or spirochetes are also known as vaccines. Vaccines are pided into live vaccines and dead vaccines. Co...


  • What are the causes of kidney disease dur
    What are the causes of kidney disease during pregnancy?

    Regarding the cause of pregnancy-induced nephropathy, experts pointed out that the etiology and pathogenesis of nephrotic syndrome are complex, and there are many factors involved, such as infection, autoimmunity, drugs, genetics, and envir...


  • What tests should kidney patients do?
    What tests should kidney patients do?

    In general, urine and kidney function should be checked promptly in patients with suspected kidney disease. These tests can initially understand the extent of the kidney disease, but if the nature of the kidney disease is still not clear, t...


  • Gout actually hurts the kidneys? ! Is gou
    Gout actually hurts the kidneys? ! Is gout kidney disease te

    According to the survey, the gout population is getting younger and younger. The peak incidence of gout patients is between 30 and 45 years old, and the number of patients is more than 1/3 of all gout patients. Gout is not only high in uric...


  • What are the causes of kidney cancer in p
    What are the causes of kidney cancer in patients with kidney

    The incidence of kidney cancer in patients with kidney disease is rising, so what are the causes of kidney cancer in patients with kidney disease? Which factors lead to a high incidence of kidney cancer? Let us understand. 1. Smoking: Smoki...


  • Children are prone to childhood kidney di
    Children are prone to childhood kidney disease in summer, wh

    Rainy summer, coupled with the use of air conditioning, childrens body conditioning ability is relatively poor, can not withstand the cold inside and outside the hot pinch, it is easy to fall ill. Since the summer, the number of children wi...


  • The meaning and results of aerobic and an
    The meaning and results of aerobic and anaerobic exercise!

    The so-called aerobic exercise is actually the body can provide enough oxygen to transport the body cells to help the production process. The advantage is that oxygen can fully burn (ie oxidize) the bodys sugar and help consume the bodys fa...


  • Blindly take stomach medicine and be care
    Blindly take stomach medicine and be careful about kidney di

    Proton pump inhibitors are a commonly used drug for the treatment of acid reflux, such as omeprazole, esomeprazole and lansoprazole. Because they can inhibit the secretion of gastric acid, they are deeply loved by some stomachaches and stom...


  • Common side effects and countermeasures o
    Common side effects and countermeasures of insulin injection

    Subcutaneous fat hyperplasia is a common side effect in patients who use insulin injections. Many long-term insulin injections in patients with diabetes have thickened rubber-like lesions in the subcutaneous tissue at the injection site, wi...


Contact Us

Popular articles
Popular video