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can statins cause kidney problems

Written by admin | Published on 2017-06-22

  

Vancouver Columbia University professor Dormuth of rosuvastatin or atorvastatin 10mg/ day, 20mg/ day, observation of three groups of patients were more than simvastatin 40mg/ days, research data from Canada, the United States and the United Kingdom in about 2000000. The results showed that compared with the low dose of statin use, these patients in the first 4 June received high dose statin therapy, the risk of acute kidney injury increased 34%.

Therefore, Professor Dormuth believes that higher doses of statins may increase the risk of patients with acute kidney injury. However, the New York University School of Medicine Professor Bangalore did not agree with this conclusion.

Professor Bangalore analysis of statins with placebo, high dose and low dose statin differences between the incidence of injury in acute kidney. Research data from the Collaborative Atorvastatin Diabetes Study (CARDS), study of atorvastatin in prevention of non-insulin-dependent diabetes mellitus patients with coronary heart disease (ASPEN), end point events by aggressive reduction in cholesterol the level of stroke prevention study (SPARCL), on dialysis patients (4D), the German diabetes therapy targeting research (TNT) as well as through intensive lipid-lowering reduce end point event study (IDEAL).

The study found that the test group and the control group, high dose and low dose statin group, kidney related serious adverse events were no significant statistical differences, statins do not increase the risk of kidney related serious adverse events. These results with PROVE IT-TIME 11 and A to data obtained in the research of Z.

However, Professor Bangalore acknowledged that their analysis of these studies are limited, not enough to find statins in kidney related serious adverse events rate differences are studied using atorvastatin, the results can be applied to other statins such as rosuvastatin, is not clear. In addition, research may underestimate the risk of kidney related adverse events.

The research data on high dose and low dose of statins from three clinical trials in Professor Dormuth IDEAL, the study occurred in 3 cases of renal adverse events, TNT of 2 cases, PROVE IT/A to Z of 43 cases. The overlapping 95% confidence interval Ci and Bangalore calculated the (actually included in the confidence interval).

Therefore, the results can not think of Professor Bangalore and Professor Dormuth, the conclusion is not consistent.

 


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