In recent years, A kidney transplant technology have made great progress, especially the cyclosporine A and other new immunosuppressant for kidney transplant, A kidney transplant has become an effective way for the treatment of end-stage diabetic nephropathy. The main factors affecting the kidney transplantation of diabetic nephrosis patients are:
1, The use of corticosteroids after transplantation makes blood sugar control more difficult;
2, Diabetic patients often have a neurogenic bladder that affects the function of the transplanted kidney;
3, People with diabetes are less immune and prone to infection;
4, Patients with diabetes often have severe cardiovascular complications that affect their long-term survival;
5, Patients with diabetes have poor blood vessel conditions, which may affect the transplant operation. At present, the survival rate of renal transplantation (ESRD) in diabetic 5, nephropathy (ESRD) has been greatly improved, with a survival rate of up to 90 percent in one year. The long-term survival of the kidney, about a third of the severe diabetic kidney damage, but the onset of diabetic nephrosis is a very slow process. So far, there are very few in diabetic patients after renal transplantation for more than 20 years, as a result, the problems of recurrence of diabetic nephropathy is not primary problems affect the outcome of renal transplantation. Kidney transplants may be considered for diabetic nephropathy, as long as the heart condition and general condition are permitted.
Kidney and pancreas transplantation can reduce the need for exogenous insulin and reduce the frequency and degree of acute hypoglycemia, improves the quality of life of allograft renal transplantation patients, and to reduce cardiovascular complications in diabetic patients, and to a certain extent to improve diabetes caused by systemic microvascular lesions. The disadvantage of the combination transplantation is that it may increase the risk of surgical mortality, longer hospital stay, and increase the risk of kidney rejection. Infections are also more common due to the need to increase the amount of immunosuppressant drugs. The simultaneous pancreas kidney transplantation is mainly suitable for younger age, Ⅰ in good general condition with type 1 diabetes.