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Is serum creatinine and high urea nitrogen are renal insufficiency?

The increase of serum creatinine and urea nitrogen in renal function is not necessarily renal insufficiency. It is affected by many factors. The quantity of muscle tissue and the state of metabolism are the major extra renal factors affecti...

Is serum creatinine and high urea nitrogen are renal insufficiency?

Oct 10, 2017 by Kidney Disease Expert

The increase of serum creatinine and urea nitrogen in renal function is not necessarily renal insufficiency. It is affected by many factors. The quantity of muscle tissue and the state of metabolism are the major extra renal factors affecting serum creatinine.

Is serum creatinine and high urea nitrogen are renal insufficiency?

Impaired muscle metabolism in patients with muscle wasting disease, pregnant women increased protein synthesis, creatinine generation decreased, serum creatinine can be slightly lower; fever can enhance the catabolism, caused by increased serum creatinine; high protein diet can cause transient increase of serum creatinine. The amount of dietary protein, digestive tract bleeding, high catabolic metabolism, pre renal factors, and cardiac dysfunction are the major renal factors affecting the level of blood urea nitrogen.

Under normal circumstances, the reabsorption of urea nitrogen is about 30%-40%, a small amount of urinary urea nitrogen when dehydration, side by side, hypovolemia, heart failure, reduced renal blood flow, renal tubular reabsorption function enhancement, urea nitrogen absorption increased, blood urea nitrogen concentration increased as prerenal azotemia; high protein diet, gastrointestinal bleeding, high metabolism, such as fever in the urea nitrogen generation increases, increase of blood urea nitrogen. Therefore, elevated blood urea nitrogen and serum creatinine do not necessarily indicate impaired glomerular function and should be combined with clinical.

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