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Analysis of the causes of hyperlipidemia in nephrotic syndro

admin TAGS: 2017-07-26 10:39

Hyperlipidemia is one of the important characteristics of nephrotic syndrome. High blood fat refers to the total cholesterol (TC) and (or) glycerol three (TG) levels are too high or high density lipoprotein cholesterol (HDL-C) levels are too low. The occurrence of hyperlipidemia is related to increased synthesis of liver lipoprotein and decreased catabolism, the related studies show that hyperlipidemia in NS has relation with function abnormality of lipoprotein metabolism related enzymes and receptors.

It has been confirmed that associated enzyme with nephrotic syndrome hyperlipidemia include: two HMG coenzyme A reductase (HMG-CoA reductase), cholesterol 7 alpha hydroxylase (CH7 alpha hydroxylase), acyl coenzyme A cholesterol acyltransferase (ACAT), lipoprotein lipase (LPL), hepatic lipase and nephrotic syndrome with hypoproteinemia, proteinuria, glucocorticoid use and reduced hunger and other factors, which were abnormal.

Studies have shown that LDL receptors, VLDL receptors and HDL receptors play an important role in maintaining cholesterol levels in plasma. The LDL receptor is the major route of clearance of cholesterol in plasma. The study found that when the nephrotic syndrome occurs, it causes LDL receptor defaults then cause lower clearance of cholesterol through density lipoprotein forms, resulting in elevated levels of plasma cholesterol and ldl. The internalization of VLDL receptor mainly refer to VLDL, so make distribution of VLDL into tissues, such as muscle, bone; VLDL receptor defect in nephropathy, the VLDL distribution in tissues decreased, elevated its levels in plasma.

This is part of the introduction of pathogenesis of hyperlipidemia in nephritic syndrome; the research on pathogenesis of hyperlipidemia in nephrotic syndrome continues, hoping to completely make clear about the pathogenesis, making the treatment method is more reasonable and effective.

Analysis of the causes of hyperlipidemia in nephrotic syndrome
Analysis of the causes of hyperlipidemia in nephrotic syndrome

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