IgA nephropathy is the most common type of chronic nephritis and 80% of patients are young adults. Different patients with IgA nephropathy, when the clinical indicators found, the response to treatment, and the huge differences in pathological manifestations, therefore, the outcome of the disease is also very different. Light only for the performance of hematuria, long-term prognosis; fierce can be expressed as acute nephritis, rapid progression to end-stage renal failure.
Which clinical indicators suggest a worsening of renal function?
Continued (more than six months) 24 hours urine protein more than 1g. Several studies suggest that patients with urinary protein less than 1 g at 24 hours have a much slower rate of disease progression than those with 24-hour urine protein greater than 3 g. Urinary protein 0.5 to 1g of the prognosis and 0.5g following the comparison between the controversial, the domestic general requirements of urinary protein less than 0.5g quantitatively more secure.
Serum creatinine at diagnosis. At present, a large study found that the incidence of serum creatinine> 111mmol / L, follow-up of 7 years, the cumulative probability of entering the terminal renal failure is greater than 26%; while the incidence of serum creatinine less than 111mmol / L, 7 years to enter the terminal phase of the probability of low At 3%. When the onset of creatinine has been elevated, suggesting a poor prognosis.
When the onset of high blood pressure or blood pressure 30mmHg. The study found that IgA nephropathy when the onset of blood pressure higher than 140 / 90mmHg or elevated blood pressure 30mmHg are adverse prognostic factors in a follow-up study observed 10-20 years, those with elevated blood pressure than those with normal blood pressure, dialysis or death Cumulative probability increased by 5-7 times. This is because high blood pressure at onset generally suggests that the patient is more severe.
In general, urinary protein in patients with IgA nephropathy lasts below 0.5g, with normal blood pressure, normal creatinine, and low risk of renal failure. The sustained urinary protein greater than 1g, poor response to treatment, creatinine increased, high blood pressure, suggesting that high risk of renal function progression.