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Basic knowledge of primary IgA nephropathy

Introduction Primary IgA nephropathy is immune pathological diagnosis name ,which is given priority to with repeated gross hematuria or microscopic hematuria ,can accompany with different degrees of proteinuria ,renal tissue is given priori...

Basic knowledge of primary IgA nephropathy

Dec 03, 2013 by Kidney Disease Expert

Introduction

Primary IgA nephropathy is immune pathological diagnosis name ,which is given priority to with repeated gross hematuria or microscopic hematuria ,can accompany with different degrees of proteinuria ,renal tissue is given priority to with IgA immune globulin sedimentary features .

Diagnosis

1.Medical history and symptoms

After upper respiratory infection (or acute gastroenteritis 、peritonitis 、osteomyelitis and so on) 1-3 days occur easily repeated gross hematuria ,continue several hours or days will turn into microscopic hematuria ,which can accompany with abdominal pain 、back pain 、muscle pain or low fever .Parts of the patients will find abnormal urine when examination ,which is the asymptomatic proteinuria or microscopic hematuria ,a few patients will have continuous gross hematuria and different degrees of proteinuria ,and can accompany with edema and high blood pressure .

2.Examination found

Most patients have no abnormal symptoms ,parts of the patients will have the symptoms of double kidney area taps 、edema and slight or middle blood pressure rise .

3.Auxiliary examination

Most are slight 、middle proteinuria(<3g/d),blood urine present polymorphism 、diversity or mixed .Parts of the patients serum IgA rise ,especially serum IgA fibronectin connection(IgA-FN)increased more meaningful .Creatinine filtration rate reduce ,serum urea nitrogen and serum creatinine increased . According to clinic can first diagnose IgA nephropathy ,after diagnosis patients must take kidney immune pathological examination .

4.Diagnosis

Should match with lupus nephritis 、purpura nephritis 、latent glomerulonephritis .Serious patients and chronic glomerular nephritis is not easily identified .

Treatment

1.general treatment

Avoid cold and excessive fatigue ,be cautious to use renal toxicity drugs .When there is infection should give antibiotic therapy .Patients with repeated chronic tonsillitis can remove the tonsil .

2.Drug therapy

1)Patients with obvious blood urine can use triptergium wilfordii glycoside 、dipyridamole、ACEI and a lot of oral vitamin C treatment .

2)Patients is similar with chronic glomerular nephritis should deal with according to glomerular nephritis .

3)Pathological examination is given priority to with crescent formation and with IgA deposits can use strengthen the plasma exchange therapy and drug therapy .

3.blood purification

Patients with acute kidney failure or have become chronic kidney failure need to take blood purification or peritoneal dialysis therapy .

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